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ea0063p208 | Diabetes, Obesity and Metabolism 1 | ECE2019

Lipoprotein apheresis during pregnancy in severe familial hypercholesterolemia – How and when should we switch treatment in the era of PCSK9 monoclonal antibodies?

Collet Tinh-Hai , Beaud Floriane , Kosinski Christophe , Monnat Alice Panchaud , Baud David , Kissling Sebastien

Introduction: Familial hypercholesterolemia (FH) is a genetic condition associated with elevated cholesterol levels and increased risk of atherosclerotic cardiovascular diseases. Lipid-lowering drugs, i.e. statins, ezetimibe and PCSK9 inhibitors (PCSK9inh) are most often combined for effective treatment of FH. While statins may be continued during pregnancy if deemed necessary, other lipid-lowering drugs lack safety data leaving little pharmacological therapeutic options in pr...

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Lipoprotein apheresis during pregnancy in severe familial hypercholesterolemia – How and when should we switch treatment in the era of PCSK9 monoclonal antibodies?

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